X-82
CAY-38765-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1013920-15-4
Formulation
A solid
Purity
≥98%
MW
439,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A multi-kinase inhibitor; inhibits VEGFR2, PDGFRβ, FLT3, and c-Kit (IC50s = 1.12, 0.13, 0.63, and 0.14 nM, respectively) and is selective for these kinases over RET and AMPKα1 (IC50s = 74.1 and 352.2 nM, respectively); inhibits VEGF-induced proliferation of HUVECs (IC50 = 31 nM); decreases VEGF-induced capillary tube formation in HUVECs at 1 µM; reduces FBS-induced migration of HUVECs at 0.01 or 0.1 µM; reduces tumor volume and growth alone and in combination with gefitinib in an HCC827 NSCLC mouse xenograft model at 80 mg/kg per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
