RI-1
CAY-24182-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
415713-60-9
Formulation
A crystalline solid
Purity
≥98%
MW
361,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types.{40763,31181} RI-1 selectively inhibits homologous recombination without inhibiting single strand annealing.{40763} It binds directly to the C319 thiol of RAD51 and inhibits oligomerization of RAD51 filaments. In vitro, RI-1 sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD50 = 16.62 µM).{40763,31181}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
