Pridopidine
CAY-38302-50 50 mg
Data Sheet: 
SDS:
SDS:
CAS
346688-38-8
Formulation
A solid
Purity
≥95%
MW
281,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Pridopidine is a ligand of sigma non-opioid intracellular receptor 1 (σ1 receptor) and a dopaminergic stabilizer.{65845,22062} It binds to the σ1 receptor and dopamine D2 receptor in the high-affinity state (Kis = 81.3 and 7,521 nM, respectively). Pridopidine (100 µmol/kg) increases striatal 3,4-dihydroxyphenylacetic acid (DOPAC) levels and locomotor activity, as well as inhibits amphetamine-induced locomotor activity, in rats.{22062} It improves motor function and reduces striatal mutant huntingtin (mHtt) aggregates in the R6/2 mouse model of Huntington’s disease when administered at doses of 5 or 6 mg/kg.{65846} Pridopidine (30 mg/kg) prevents muscle atrophy and the loss of innervated neuromuscular junctions in the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS).{65847}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
