MKC8866
CAY-37332-5 5 mg
Synonyms: Inositol-Requiring Enzyme 1α Inhibitor 8866|IRE1-IN-8866
Data Sheet: 
SDS:
SDS:
CAS
1338934-59-0
Formulation
A solid
Purity
≥98%
MW
361,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of IRE1α RNase activity (IC50 = 0.29 µM); inhibits DTT-induced production of XBP1 in MM.1S multiple myeloma cells (EC50 = 0.52 µM) and thapsigargin-induced XBP1 production in LNCaP cells (IC50 = 0.38 µM); decreases expression of the XBP1 target genes SREBF1, DGAT2, and LIPE and increases triglyceride levels in MDA-MB-231 cells; reduces tumor volume in LNCaP, VCaP, 22Rv1, and C4-2B prostate cancer mouse xenograft models at 300 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
