Cyclosporin A
AG-CN2-0079-G001 1 g
Synonyms: Antibiotic S 7481F1; Ciclosporin A; CsA; Cyclosporine; NSC 290193; Ramihyphin A
Data Sheet: 
SDS:
SDS:
Source / Host
Isolated from Tolypocladium inflatum.
CAS
59865-13-3
Purity
>98%
MW
1202.6
Shipment
AMBIENT
Short Term Storage
+4°C
Long Term Storage
-20°C
Shelf Life
Stable for at least 3 years after receipt when stored at -20°C.
Description
Chemical. CAS: 59865-13-3. Formula: C62H111N11O12. MW: 1202.6. Isolated from Tolypocladium inflatum. Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis and autophagy inducer. Inhibits nitric oxide synthesis induced by interleukin-1alpha, lipopolysaccharides and TNF-alpha. Potently induces highly cardiogenic progenitors from embryonic stem (ES) cells.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
