Bobcat 339

  CAY-31453-50 50 mg

Data Sheet:     SDS:    

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2280037-51-4  

A crystalline solid  

≥98%  

297,7  

-20  

-20  

1460  

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Description

 

Bobcat 339 is a cytosine derivative that was originally found to be an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively, in cell-free assays).{61034} However, it was found that the TET inhibitory activity was due to residual copper in the Bobcat 339 preparation used for the experiments.{65280} Copper-containing Bobcat 339 (10 µM) also reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons, but copper-free preparations of Bobcat 339 (50 µM) do not reduce DNA 5-hmC levels in Hep3B cells.{61034,65280}

 

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