INDIGO Biosciences
INDIGO Biosciences, Inc. è un produttore di State College, Pennsylvania. Offre il più ampio portafoglio al mondo di kit e servizi per Recettori Nucleari, altri target farmacologici e soluzioni tossicologiche in vitro. Sistemi pronti basati su cellule ingegnerizzate che includono luciferasi: Androgen Receptor, AR; Aryl Hydrocarbon Receptor, AhR; Constitutive Androstane Receptor; Estrogen Receptor, ERα, ERβ; Farnesoid X Receptor, FXR; Glucocorticoid Receptor, GR; Liver Receptor Homolog-1, LRH-1; Liver X Receptor, LXRα, LXRβ; Mineralocorticoid Receptor, MR; Nuclear Factor of Activated T cells, NFAT; Nuclear Factor (erythroid-derived 2)-like 2, Nrf2; Peroxisome Proliferator-Activated Receptor, PPARα, PPARβ/δ, PPARγ; Pregnane X Receptor, PXR; Progesterone Receptor, PGR; Retinoic Acid Receptor, RARα, RARβ, RARγ; RAR-related Orphan Receptor, RORα, RORγ; Retinoid X Receptor, RXRα, RXRβ, RXRγ; TEAD4/YAP (Hippo Pathway); Thyroid Hormone Receptor, TRα, TRβ; Vitamin D Receptor, VDR. Molti di questi kit sono disponibili anche per geni ortologhi di numerose specie animali.
Epidermal Growth Factor Receptor 1, EGFR1, Growth Hormone Receptor, GHR; Nuclear Factor kappa-light-chain enhancer of activated B cells, NF-kB; Transforming Human Growth Factor Beta Receptor I/II, TGFβR; Vascular Endothelial Growth Factor Receptor 2, VEGFR2.
Toxicology Assays:
In vitro Screening for Drug-Induced Hepatotoxicity Kit (code ULC1003-48)
Human MDR1 / P-Glycoprotein Drug Interaction Assay (code HPGP-48)
Expression Profiling of Clinically Relevant CYPs Utilizing upcyte® Hepatocytes (code UGE1003-48)
The Nuclear Receptor Experts, provides a line of all-inclusive ready to use cell-based luciferase reporter Nuclear Receptor Assay Kits, GPCR Assay Kits, Transcription Factor Assay Kits, Growth Factor Receptor Assay Kits, Cytokine Receptor Assay Kits for Drug Discovery: Lead Discovery/Optimization, ADME/Safety Pharmacology and Environmental Toxicology Assays, Water Reuse Assays
Activator Protein-1 (AP-1)
Adrenoceptor Alpha 2A (ADRA2A)
Adrenoreceptor Alpha 1B (ADRA1B)
Adrenoreceptor Alpha 1D (ADRA1D)
Adrenoreceptor Beta 1 (ADRB1)
Adrenoreceptor Beta 2 (ADRB2)
Androgen Receptor (AR, NR3C4)
Arginine Vasopressin Receptor 1A (AVPR1A)
Arginine Vasopressin Receptor 1B (AVPR1B)
Arginine Vasopressin Receptor 2 (AVPR2)
Aryl Hydrocarbon Receptor (AhR)
Cannabinoid Type 1 Receptor (CB1R)
Constitutive Androstane Receptor (CAR, NR1I1)
Constitutive Androstane Receptor-2 (CAR-2, NR1I3i2)
Constitutive Androstane Receptor-3 (CAR-3, NR1I3i3)
Epidermal Growth Factor Receptor 1 (EGFR1)
Erythropoietin Receptor (EPOR)
Estrogen Receptor Alpha & Beta (ERa & ERb)
Estrogen Receptor Alpha (ERa, NR3A1)
Estrogen Receptor Beta (ERb, NR3A2)
Estrogen-related Receptor Alpha (ERRa, NR3B1)
Estrogen-related Receptor Beta (ERRβ, NR3B2)
Estrogen-related Receptor Gamma (ERRg, NR3B3)
Expression Profiling of Clinically Relevant CYPs
Farnesoid X Receptor (FXR, NR1H4)
Fibroblast Growth Factor Receptor 1 & 2 (FGFR1/2)
Fibroblast Growth Factor Receptor 1c and β-Klotho (FGFR/β-Klotho)
Fibroblast Growth Factor Receptor 4 and α-Klotho (FGFR4/α-Klotho)
G Protein-Coupled Bile Acid Receptor (TGR5; GPBAR1)
Gastric Inhibitory Polypeptide Receptor (GIPR)
Glucagon-Like Peptide-1 Receptor
Glucocorticoid Receptor (GR, NR3C1)
Growth Hormone Receptor (GHR)
Hepatocyte Nuclear Factor 4 alpha (HNFa, NR2A1)
in vitro Screening for Drug-Induced Hepatotoxicity
Insulin Receptor, isoform B
Insulin-Like Growth Factor Receptor 1
Liver X Receptor Alpha & Beta (LXRa & LXRb)
Liver X Receptor Alpha (LXRa, NR1H3)
Liver X Receptor Beta (LXRb, NR1H2)
LRH-1 (Human Liver Homolog Receptor-1)
Mineralocorticoid Receptor (MR, NR3C2)
Nuclear Factor of Activated T cells (NFAT)
Nuclear Factor (erythroid-derived 2)-like 2 (Nrf2)
Nuclear Factor kappa-light-chain enhancer of activated B cells (NF-kB)
Oxytocin Receptor (OXTR)
P-Glycoprotein / MDR1 Drug Interaction
Peroxisome Proliferator-Activated Receptor Alpha (PPARa, NR1C1)
Peroxisome Proliferator-Activated Receptor Alpha, Delta, & Gamma (PPARa, PPARd, PPARg)
Peroxisome Proliferator-Activated Receptor Delta (PPARd / PPARb, NR1C2)
Peroxisome Proliferator-Activated Receptor Delta (PPARd, NR1C2)
Peroxisome Proliferator-Activated Receptor Gamma (PPARg, NR1C3)
Platelet-Derived Growth Factor Receptors alpha & beta
Pregnane X Receptor (PXR, NR1I2)
Progesterone Receptor (PGR, NR3C3)
RAR-related Orphan Receptor Alpha (RORa, NR1F1)
RAR-related Orphan Receptor Gamma (RORg, NR1F3)
Retinoic Acid Receptor Alpha (RARa, NR1B1)
Retinoic Acid Receptor Alpha, Beta, & Gamma (RARa, RARb, & RARg)
Retinoic Acid Receptor Beta (RARb, NR1B2)
Retinoic Acid Receptor Gamma (RARg, NR1B3)
Retinoid X Receptor Alpha (RXRa, NR2B1)
Retinoid X Receptor Alpha, Beta, & Gamma (RXRa, RXRb, & RXRg)
Retinoid X Receptor Beta (RXRb, NR2B2)
Retinoid X Receptor Gamma (RXRg, NR2B3)
TEAD4/YAP (Hippo Pathway)
Thrombopoietin Receptor (TPOR)
Thyroid Hormone Receptor Alpha & Beta (TRa & TRb)
Thyroid Hormone Receptor Alpha (TRa, NR1A1)
Thyroid Hormone Receptor Beta (TRb, NR1A2)
Transforming Human Growth Factor beta Receptor (TGFbR)
Tropomysin Receptor Kinase A (TrkA; NTRK1)
Tropomysin Receptor Kinase B (TrkB; NTRK2)
Tropomysin Receptor Kinase C (TrkC; NTRK3)
Tumor Protein 53 (p53)
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)
Vitamin D Receptor (VDR, NR1I1)