p21 Antibody / CDKN1A
NSJ-V2433-100UG 100 ug
Data Sheet: 
Reactivity
Human
Applications
IF, WB, IHC-P
Source / Host
Mouse
Immunogen
Recombinant full-length human protein was used as the immunogen for the p21 antibody.
Clone
CIP1/823
Purity
Protein G affinity chromatography
Long Term Storage
Store the p21 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Description
This mAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This mAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
