iKIX1
CAY-19839-5 5 mg
Data Sheet: 
CAS
656222-54-7
Formulation
A crystalline solid
Purity
≥98%
MW
303,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of interactions between the transcription co-activator Mediator complex and the CgPdr1 transcription factor in the pathogen C. glabrata; inhibits the interaction between the KIX domain of the Mediator subunit CgGal11A and the activation domain of CgPdr1 (IC50 = 190.2 μM); inhibits ketoconazole-induced expression of CgPdr1-target genes involved in multidrug resistance and drug efflux in C. glabrata at 10 and 30 μM; increases the sensitivity of azole-resistant C. glabrata strains expressing CgPDR1 gain-of-function mutations to fluconazole and ketoconazole; decreases fungal burden in the kidney and spleen in a mouse model of infection with azole-sensitive or -resistant C. glabrata at 100 mg/kg when administered in combination with low and high doses of fluconazole, respectively
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
