anti-Acetyl-Histone H2A.X (Lys5), Rabbit Monoclonal (RM445)

  REV-31-1336-00-C025 25 µg

Data Sheet:    

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Human, All Vertebrates  

WB, Multiplex  

Rabbit  

This antibody reacts to Histone H2A.X acetylated at Lysine 5 (K5ac). It shows no cross-reactivity with non-modified Lysine 5 or other acetylated Lysines in histone H2A.  

RM445  

Protein A purified.  

BLUE ICE  

-20°C  

Stable for at least 1 year after receipt when stored at -20°C.  

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Description

 

Recombinant Antibody. This antibody reacts to Histone H2A.X acetylated at Lysine 5 (K5ac). It shows no cross-reactivity with non-modified Lysine 5 or other acetylated Lysines in histone H2A. Applications: WB, Multiplex. Clone: RM445. Isotype: Rabbit IgG. Formulation: Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Histones are proteins that package DNA into nucleosomes. Histones are responsible for maintaining the shape and structure of a nucleosome. One chromatin molecule is composed of at least one of each core histones per 100 base pairs of DNA. There are five families of histones known to date; these histones are termed H1/H5, H2A, H2B, H3, and H4. H2A is considered a core histone, along with H2B, H3 and H4. Core formation first occurs through the interaction of two H2A molecules. Then, H2A forms a dimer with H2B; the core molecule is complete when H3-H4 also attaches to form a tetramer. Histone H2A is composed of non-allelic variants, including H2A.1, H2A.2, H2A.X, and H2A.Z. H2A packages DNA molecules into chromatin and has been correlated with DNA modification and epigenetics. H2A plays a major role in determining the overall structure of chromatin and regulates gene expression. Protein modification on histone H2A exist and can sometimes result in a change in function. Different H2A variants were exploited to have different functions, genetic sequences and modifications.

 

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