anti-5-Methylcytosine, Rabbit Monoclonal (RM231)
REV-31-1110-00-C050 50 µg
Synonyms: 5-mC
Data Sheet: 
Reactivity
All Vertebrates
Applications
ELISA, FACS, ICC, IHC, DotBlot, MeDIP
Source / Host
Rabbit
Specificity
This antibody reacts to 5-methylcytosine in both single-stranded and double-stranded DNA. No cross reactivity with non-methylated cytosine and hydroxymethylcytosine in DNA.
Clone
RM231
Purity
Protein A purified.
Shipment
BLUE ICE
Long Term Storage
-20°C
Shelf Life
Stable for at least 1 year after receipt when stored at -20°C.
Description
Recombinant Antibody. This antibody reacts to 5-methylcytosine in both single-stranded and double-stranded DNA. No cross reactivity with non-methylated cytosine and hydroxymethylcytosine in DNA. Applications: DotBlot, MeDIP, ICC, IHC, ELISA, FC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. 5-Methylcytosine is a methylated form of the DNA base cytosine that regulates gene transcription and is involved in epigenetics. It is one of the best known epigentic modifications. This methylation typically occurs at cytosine in CpG dinucleotides in vertebrates. When cytosine is methylated, the DNA maintains the same sequence, but the expression of methylated genes can be altered. 5-Methylcytosine is a very important repressor of transcription in the genome. When present in promoters, 5-Methylcytosine is associated with stable, long-term transcriptional silencing. This may occur by either blocking positive transcription factors, or promoting the binding of negative ones.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
