anti-5-Hydroxymethylcytosine, Rabbit Monoclonal (RM236)
REV-31-1111-00-C050 50 µg
Synonyms: 5-hmC
Data Sheet: 
Reactivity
All Vertebrates
Applications
ELISA, FACS, ICC, IHC, DotBlot, MeDIP
Source / Host
Rabbit
Specificity
This antibody reacts to 5-hydroxymethylcytosine in both single-stranded and double-stranded DNA. No cross reactivity with non-methylated cytosine and methylcytosine in DNA.
Clone
RM236
Purity
Protein A purified.
Shipment
BLUE ICE
Long Term Storage
-20°C
Shelf Life
Stable for at least 1 year after receipt when stored at -20°C.
Description
Recombinant Antibody. This antibody reacts to 5-hydroxymethylcytosine in both single-stranded and double-stranded DNA. No cross reactivity with non-methylated cytosine and methylcytosine in DNA. Applications: DotBlot, MeDIP, ICC, IHC, ELISA, FC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. 5-Hydroxymethylcytosine (5hmC) is the first oxidative product in the active demethylation of 5-methylcytosine (5mC). It not only marks active demethylation but also serves as a relatively stable DNA mark that plays distinct epigenetic roles. It is potentially important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. 5hmC is abundantly expressed, but the levels vary significantly depending on the cell type. The highest levels are found in neuronal cells of the central nervous system.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
