ZM 449829
CAY-32820-25 25 mg
Synonyms: JAK3 Inhibitor V|Janus-Associated Kinase 3 Inhibitor V
Data Sheet: 
SDS:
SDS:
CAS
4452-06-6
Formulation
A crystalline solid
Purity
≥95%
MW
182,2179
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of JAK3 (IC50 = 0.158 µM) and a degradation product of ZM 329923; selective for JAK3 over EGFR and JAK1 (IC50s = 10 and 19.95 µM, respectively) but does inhibit TGM2 and FXIIIa (IC50s = 0.005 and 0.006 µM, respectively); decreases the formation of CSC within MCF-7-derived mammospheres; decreases migration of, and colony formation by, MCF-7 cells at 10 µM; inhibits formation of replication vacuoles in C. burnetii-infected HeLa and THP-1 cells at 10 µM
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
