XMU-MP-1
CAY-22083-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
2061980-01-4
Formulation
A solid
Purity
≥98%
MW
416,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of MST1 and MST2 (IC50s = 71.1 and 38.1 nM, respectively); is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM; inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner; prevents cell death induced by overexpression of MST2; enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury when administered at a dose of 1 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
