XL184
CAY-18464-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
849217-68-1
Formulation
A crystalline solid
Purity
≥98%
MW
501,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A VEGFR2 inhibitor (IC50 = 0.035 nM); selective for VEGFR2 over Ron, EGFR, IGF-1R, and EphA4/B4; inhibits c-Met, RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 1.3, 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively); inhibits VEGF-induced tubule formation in HMVECs at 4.6 nM; reduces HGF-induced migration and invasion of B16/F10 cells at 123 nM; induces tumor regression in an MDA-MB-231 breast cancer mouse xenograft model at 60 mg/kg; does not increase the number of pulmonary tumor foci in an MDA-MB-231 mouse metastasis model; protects primary placental fibroblasts from Zika virus infection
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
