Thymidylate Synthase Antibody
NSJ-V3515-100UG 100 ug
Data Sheet: 
Reactivity
Human
Applications
FACS, IF, WB, IHC-P
Source / Host
Mouse
Immunogen
A recombinant human parital protein corresponding to amino acids 60-174 was used as the immunogen for this TYMS antibody.
Clone
TYMS/1884
Purity
Protein G affinity chromatography
Long Term Storage
Store the TYMS antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Description
This antibody recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS, TYMS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
