TCS 5861528
CAY-18380-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
332117-28-9
Formulation
A crystalline solid
Purity
≥98%
MW
369,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse, potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. TCS 5861528 is a selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (Item No. 32100) with IC50 values of 14.3 and 18.7 μM, respectively.{29617,22996} At 30 mg/kg twice daily in rats, TCS 5861528 has been used to attenuate pain-related behavior in models of diabetic hypersensitivity and postoperative pain.{29617,24757}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
