TC-FPR 43
CAY-29804-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
903895-98-7
Formulation
A crystalline solid
Purity
≥98%
MW
384,9
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
TC-FPR 43 is an agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1).{52690,52691} TC-FPR 43 induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner.{52691} TC-FPR 43 inhibits migration of polymorphonuclear (PMN) neutrophils induced by fMLP (Item No. 21495) or IL-8 with IC50 values of 0.64 and 0.24 µM, respectively.{52690} It also reduces ear swelling induced by prostaglandin E2 (PGE2; Item No. 14010) and leukotriene B4 (LTB4; Item No. 20110) in mice when administered at a dose of 50 mg/kg.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
