Streptozotocin
CAY-13104-50 50 mg
Synonyms: Estreptozocin|NSC 37917|NSC 85998|Streptozocin|STZ|U 9889
Data Sheet: 
SDS:
SDS:
CAS
18883-66-4
Formulation
A crystalline solid
Purity
≥95% (mixture of isomers)
MW
265,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals.{21671,21669} It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA.{21670,21667} DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.{21671} The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.{21669,21668}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
