Solamargine
CAY-28110-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
20311-51-7
Formulation
A crystalline solid
Purity
≥95%
MW
868,1
Shipment
-20
Long Term Storage
-20
Shelf Life
730
Description
Solamargine is a glycoalkaloid that has been found in S. lycocarpum and has anticancer activity.{49236} It decreases viability of H1650, H1975, PC-9, A549, and H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 6 µM. Solamargine increases ERK1/2 phosphorylation and decreases the expression of DNA methyltranferase 1 (DNMT1) in H1299 and A549 cells. It reduces tumor growth in an A549 mouse xenograft model when administered at a dose of 8 mg/kg per day. Solamargine increases ERK1/2 phosphorylation and reduces the expression of the prostaglandin E2 receptor, DNMT1, and c-Jun in tumor tissue.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
