Sirtinol
CAY-10523-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
410536-97-9
Formulation
A crystalline solid
Purity
≥98%
MW
394,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 μM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 μM, respectively.{15174} It does not alter HDAC1 activity.{15174} Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.{20764,20761,20763} In plants, sirtinol can be metabolized to 2-hydroxy-1-naphthoic acid, which activates auxin signaling and alters plant growth and development.{20765,20762}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
