STM2457
CAY-34280-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
2499663-01-1
Formulation
A solid
Purity
≥98%
MW
444,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
STM2457 is an inhibitor of the methyltransferase-like 3 (METTL3) and METTL14 complex (IC50 = 16.9 µM).{59966} It inhibits growth in a panel of acute myeloid leukemia (AML) cell lines (IC50s = 0.6-10.3 µM). STM2457 also inhibits the proliferation, migration, and invasion of HuCC-T1 and HCCC-9810 intrahepatic cholangiocarcinoma (ICC) cells in a concentration-dependent manner.{69159} It increases survival in a patient-derived xenograft (PDX) mouse model of AML when administered at a dose of 50 mg/kg.{59966}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
