SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Monoclonal Antibody (Clone 08)

  CAY-31984-100 100 µl

Data Sheet:     SDS:    

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ELISA, FC, IHC-P, WB  

Mouse  

Recombinant SARS-CoV nucleocapsid protein  

8  

IgG1  

50 or 100 µl of protein A-affinity purified monoclonal antibody  

0  

-80  

-80  

365  

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Description

 

Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 nucleocapsid proteins are encoded by the N gene in SARS-CoV and SARS-CoV-2 RNA.{53462,62041} SARS-CoV and SARS-CoV-2 are members of the Betacoronavirus genus of viruses that have approximately 79% sequence identity and share 27 T cell epitopes in common.{53459,53461,49555} The SARS-CoV-2 nucleocapsid protein has greater than 90% similarity to the SARS-CoV nucleocapsid protein and contains two unique B cell epitopes and two T cell epitopes that are structurally stable, non-allergenic, and induce production of IFN-γ.{49555,62041} SARS-CoV and SARS-CoV-2 nucleocapsid proteins package the viral RNA into a helical ribonucleoprotein complex (RNP), which is a template for viral replication, and are integral for viral self-assembly and involved in regulation of the host cell cycle.{53460,62041} SARS-CoV and SARS-CoV-2 are the causative agents of SARS and COVID-19, respectively, both of which are primarily respiratory illnesses characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.{53461,55257,55258} Cayman's SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Monoclonal Antibody (Clone 08) can be used for ELISA, flow cytometry (FC), immunohistochemistry-paraffin (IHC-P), and Western blot (WB) applications. The antibody recognizes wild-type and various mutant nucleocapsid proteins at 45.6 kDa from SARS-CoV, SARS-CoV-2, and several SARS-CoV-2 Alpha, Beta, Gamma, Delta, Eta, and Omicron subvariants.

 

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