Roflumilast-d4
CAY-18260-500 500 µg
Data Sheet: 
SDS:
SDS:
CAS
1398065-69-4
Formulation
A solid
Purity
≥99% deuterated forms (d1-d4)
MW
407,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Roflumilast-d4 is intended for use as an internal standard for the quantification of roflumilast (Item No. 15141) by GC- or LC-MS. Roflumilast is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 0.8 nM).{49692} It is selective for PDE4 over PDE1, -2, -3, and -5 (IC50s = >10, >10, >10, and 8 µM, respectively). Roflumilast inhibits the production of leukotriene B4 (LTB4; Item No. 20110) induced by fMLP (Item No. 21495) in isolated human neutrophils with an IC50 value of 2 nM. It reduces the proliferation of anti-CD3 and anti-CD28-stimulated isolated human CD4+ T cells (IC30 = 7 nM). Roflumilast (5 mg/kg) prevents pulmonary inflammatory cell infiltration and emphysema in mice exposed to cigarette smoke.{62535} Formulations containing roflumilast have been used in the treatment of chronic obstructive pulmonary disease (COPD).
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
