R1487 (hydrochloride)
CAY-31478-10 10 mg
Data Sheet: 
CAS
449808-64-4
Formulation
A crystalline solid
Purity
≥98%
MW
424,828826
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of p38α MAPK (IC50 = 10 nM); selective for p38α over p38β MAPK (Kds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by >85% at 10 µM; inhibits LPS-induced IL-1β production in isolated human whole blood (IC50 = 170 nM); inhibits LPS-induced production of TNF-α and IL-6 in rats (ED50s = 0.8 and 0.4 mg/kg); reduces yeast-induced hyperalgesia in rats (ED50 = 5.5 mg/kg)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
