Procyanidin A2
CAY-25200-10 10 mg
Synonyms: (+)-Epicatechin-(4β-8,2β-O-7)-epicatechin|Proanthocyanidin A2|Procyanidin dimer A2|Procyanidol A2
Data Sheet: 
SDS:
SDS:
CAS
41743-41-3
Formulation
A solid
Purity
≥95%
MW
576,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Procyanidin A2 is a natural flavanol dimer of (–)–epicatechin (Item No. 11807) that is found in the horse chestnut (A. hippocastanum), mountain cranberry (V. vitis-idaea), and other fruits with antioxidant, anti-inflammatory, antibacterial, antiproliferative, and antidiabetic properties.{39743,39744,39745,39746,39747} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50 = 5.08 μM) and inhibits STAT3 activation induced by platelet derived growth factor (PDGF) in primary rat vascular smooth muscle cells (VSMCs) when used at a concentration of 30 μg/ml.{39745,39746} Procyanidin A2 inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml, respectively) and proliferation of human HepG2 liver hepatocellular carcinoma and HeLa cervical cancer cells (EC50s = 62.19 and 66.07 μg/ml, respectively).{39745} It also increases insulin secretion from primary mouse pancreatic islets when used at a concentration of 10 μM in vitro and inhibits bisphenol A-induced glucose increases in fasted mice when administered at a dose of 10 μmol/kg per day.{39747}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
