Piclidenoson
CAY-28445-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
152918-18-8
Formulation
A crystalline solid
Purity
≥98%
MW
510,3
Shipment
-20
Long Term Storage
-20
Shelf Life
730
Description
Piclidenoson is an adenosine A3 receptor agonist (Ki = 1.7 nM).{52557} It is selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively). In vivo, piclidenoson (100 µg/kg) reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion, an effect that can be reversed by the adenosine receptor antagonist 8-p-sulfophenyl theophylline.{52556} It reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and decreases the number of lung metastases in a model of metastatic murine melanoma.{52557} Piclidenoson (1 and 3 mg/kg) also reduces colonic inflammatory cell infiltration and damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250) and in IL-10-/- mice.{52558}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
