PROTAC® Optimization Kit for CDK Kinase-Cereblon Binding
BPS-79924 384 reactions
Data Sheet: 
Applications
Great for identifying and optimizing PROTACs targeting the CDK family of kinases, the design of novel molecules targeting CRBN, and comparison of activities of different PROTACs.
Shipment
-80°C (dry ice)
Literature References
Brand, M., et al. Cell Chem. Biol. 2019; 26(2):300-306.
Description
The PROTAC Optimization Kit for CDK Kinase-Cereblon Binding is designed for testing and profiling of PROTACs directed against the CDK Kinase family and Cereblon. Cereblon (CRBN) is a Substrate recognition component of the DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
The CDK inhibitor Palbociclib is included as a control inhibitor of PROTAC binding to CDK. With this kit, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and CDK4 or CDK6 Kinase. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts. - Great for identifying and optimizing PROTACs targeting the CDK family of kinases, the design of novel molecules targeting CRBN, and comparison of activities of different PROTACs. - BSJ-03-204 is a thalidomide-derivative, which is known to cause severe birth defects in humans. It is very important to use all appropriate precautions when handling this compound.
The CDK inhibitor Palbociclib is included as a control inhibitor of PROTAC binding to CDK. With this kit, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and CDK4 or CDK6 Kinase. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts. - Great for identifying and optimizing PROTACs targeting the CDK family of kinases, the design of novel molecules targeting CRBN, and comparison of activities of different PROTACs. - BSJ-03-204 is a thalidomide-derivative, which is known to cause severe birth defects in humans. It is very important to use all appropriate precautions when handling this compound.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
