PQR620
CAY-26656-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1927857-56-4
Formulation
A solid
Purity
≥98%
MW
445,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
PQR620 is an inhibitor of mTOR (Ki = 10.8 nM).{49937} It is selective for mTOR over PI3K p110α (Ki = 4.2 µM) and a panel of 456 other kinases at 10 µM. PQR620 has antiproliferative activity against a panel of 66 cancer cell lines (mean IC50 = 919 nM). It induces cell cycle arrest at the G1 phase in A2058 melanoma and SKOV3 ovarian cancer cells when used at a concentration of 5 µM. In vivo, PQR620 (100 mg/kg per day) decreases the number of seizures per week in a Tsc1GFAP conditional knockout mouse model of epilepsy to a similar extent as PQR530 (Item No. 28563).{58361}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
