PMS1 Antibody / PMS1 protein homolog 1
NSJ-V9715-100UG 100 ug
Data Sheet: 
Reactivity
Human
Applications
ELISA, FACS, IF
Source / Host
Mouse
Immunogen
Recombinant full-length human PMS1 protein was used as the immunogen for the PMS1 antibody.
Clone
PCRP-PMS1-2E11
Purity
Protein A/G affinity
Long Term Storage
Aliquot the PMS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Description
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
