PI-1840
CAY-37331-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1401223-22-0
Formulation
A solid
Purity
≥98%
MW
394,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of chymotrypsin-like proteasome activity (IC50 = 27 nM); selective for the CTL activity over the TL and PGPH activities (IC50s = >100 µM for both), as well as for the 20S constitutive proteasome over the immunoproteasome (IC50s = 18 and 2,170 nM, respectively); decreases the viability of a panel of cancer cell lines (IC50s = 2.2-45.2 µM); induces cell cycle arrest at the G2/M phase, apoptosis, and autophagy, as well as inhibits migration and invasion, in U2OS and MG-63 cells at 40 and 60 µM, respectively; decreases tumor volume in an MDA-MB-231 breast cancer mouse xenograft model at 150 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
