PHA-680632
CAY-28381-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
398493-79-3
Formulation
A crystalline solid
Purity
≥98%
MW
501,62348
Shipment
-20
Long Term Storage
-20
Shelf Life
730
Description
An inhibitor of Aurora A, B, and C kinases (IC50s = 27, 135, and 120 nM, respectively); has >15-fold selectivity for Aurora A kinase in a panel of 31 kinases; inhibits phosphorylation of serine 10 on histone H3 in U2OS cells (IC50 = 0.39 µM); inhibits proliferation of U2OS, HeLa, A549, HCT116, U937, and HL-60 cancer cell lines (IC50s = 1.6, 0.4, 0.6, 0.1, 0.1, and 0.1 µM, respectively); reduces the size of established tumors in transgenic v-Ha-ras mice and in an HL-60 human leukemia xenograft mouse model when administered at a dose of 45 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
