PFI-4
CAY-17663-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
900305-37-5
Formulation
A crystalline solid
Purity
≥98%
MW
380,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators.{21051,29177} BRPF1, aka BR140 or Peregrin, is important for maintaining Hox gene expression and the development of multiple tissues, axial skeleton, and the hematopoietic system.{29177} PFI-4 is a chemical probe that specifically binds to the bromodomain of BRPF1 (Kd = 13 nM), inhibiting binding to tri-acetylated histone 4 (residues 1-21).{29176} It has much lower affinity for bromodomain 1 of BRD4 (Kd = >50 µM) and is selective for BRPF1 over BRPF2 and BRPF3.{29176} PFI-4 is potent in cells, with an IC50 value of 250 nM. See the Structural Genomics Consortium (SGC) website for more information.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
