PF-429242 (hydrochloride)
CAY-15140-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
2248666-66-0
Formulation
A crystalline solid
Purity
≥95%
MW
482,5
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A site-1 protease inhibitor (IC50 =170 nM against human recombinant site-1 protease); selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 μM; inhibits proteolytic processing and nuclear translocation of SREBP; reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 μM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells; reduces cholesterol and fatty acid synthesis in CD-1 mice; inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells; reduces growth of T98G, U87-MG, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 μM, respectively)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
