PD 173955
CAY-30618-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
260415-63-2
Formulation
A crystalline solid
Purity
≥98%
MW
443,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A tyrosine kinase inhibitor; inhibits c-Src, Yes, and LCK (IC50s = 25, 22, and 5 nM, respectively), as well as Bcr-Abl and c-Kit (IC50s = 1-2 and 25 nM, respectively), and is selective for these kinases over InsR, α-FGFR, bFGFR, PDGFR, and PKC; induces cell cycle arrest at the G2/M phase in DU145 prostate, SKOV3 ovarian, HT-29 colon, A549 lung, and A431 skin cancer cell at 5,000 nM; inhibits proliferation of MDA-MB-468 and MCF-7 breast cancer cells (IC50s = 500 and 1,000 nM, respectively), as well as patient-derived peripheral blood CML progenitor cells (IC50= ~7.5 nM)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
