Methysergide (maleate)
CAY-27658-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
129-49-7
Formulation
A crystalline solid
Purity
≥95%
MW
469,53026
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A 5-HT1 receptor agonist and 5-HT2 receptor antagonist; binds to recombinant human 5-HT1A (KD = 23.44 nM), 5-HT1E (Ki = 229.09 nM), 5-HT1F (Ki = 33.88 nM), and rodent 5-HT1B receptors (KD = 1,513.56 nM); binds to recombinant human 5-HT2A (Ki = 2.69 nM) and 5-HT2C receptors (KD = 1.26 nM) and is an insurmountable antagonist at 5-HT2B receptors; inhibits 5-HT-induced vasoconstriction in isolated postmortem human basilar arterial spiral strips (pA2 = 8.07); decreases external carotid blood flow in a dose-dependent manner in vagosympathectomized dogs; has antinociceptive activity in mouse models of pain induced by substance P, glutamate, NMDA, AMPA, or kainic acid; reduces zymosan-induced paw edema in rats at 10 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
