Leniolisib
CAY-28078-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1354690-24-6
Formulation
A crystalline solid
Purity
≥98% (mixture of rotamers)
MW
450,457649
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of PI3Kδ (IC50 = 0.011 µM); selective for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC50s = 0.244, 0.424, and 2.23 µM, respectively); inhibits phosphorylation of Akt in Rat-1 fibroblasts expressing P13K p110δ (IC50 = 0.056 µM); inhibits the MLR in isolated human PBMCs and isolated mouse splenocytes (IC50s = 0.079 and 0.033 µM, respectively); reduces the production of rat anti-rat collagen antibodies, as well as reduces paw swelling and joint erosion in a rat model of collagen-induced arthritis at 3 and 10 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
