L-778,123 (hydrochloride)
CAY-22940-50 50 mg
Data Sheet: 
SDS:
SDS:
CAS
253863-00-2
Formulation
A crystalline solid
Purity
≥98%
MW
442,3
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A dual inhibitor of FTase and GGTase I (IC50s = 2 and 98 nM, respectively); inhibits prenylation of FTase and GGTase I substrates HDJ2 and RAP1A in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively); inhibits prenylation of the oncogenic protein KI-RAS in PSN-1 cells in a concentration-dependent manner; reduces HDJ2 and RAP1A prenylation ex vivo in dog PBMCs when administered at a dose of 35-50 mg/kg per day; has no effect on KI-RAS prenylation in patient-derived PBMCs; inhibits lectin-induced expression of the T cell activation markers CD71 and CD25 on human PMBCs (IC50s = 6.48 and 84.1 μM, respectively); inhibits IL-2-induced proliferation of CTLL-2 cells (IC50 = 0.81 μM)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
