L-745,870 (hydrochloride)
CAY-37586-50 50 mg
Data Sheet: 
SDS:
SDS:
CAS
866021-03-6
Formulation
A solid
Purity
≥98%
MW
472,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A dopamine D4 receptor antagonist (Ki = 0.43 nM); selective for dopamine D4 receptors over dopamine D2 and D3 receptors (Kis = 960 and 2,300 nM, respectively); selective for dopamine D4 receptors over α2A-, α2B-, and α2C-adrenergic receptors (IC50s = 0.00043, 0.16, 0.17, and 0.23 µM, respectively) and 5-HT2C and 5-HT1A receptors (IC50s = 0.2 and 2.9 µM, respectively); inhibits dopamine-induced inhibition of forskolin-induced cAMP production in HEK293 cells expressing human dopamine D4 receptors at 100 nM; inhibits mescaline-induced head twitches in mice at 3, 10, and 30 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
