KRAS (G12C) Isoform A Coupled Nucleotide Exchange (TR-FRET) Assay Kit
BPS-82709 384 reactions
Data Sheet: 
Reactivity
Human
Applications
Screen small molecule inhibitors or antagonists that affect KRAS(G12C) nucleotide-binding status in high throughput screening (HTS) applications.
Shipment
-80°C (dry ice)
Description
The KRAS (G12C) Isoform A Coupled Nucleotide Exchange TR-FRET Assay Kit is a TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) assay kit designed for screening and profiling of KRAS (Kirsten rat sarcoma) (G12C) antagonists/inhibitors. It monitors the binding of an effector protein such as the Ras binding domain of Raf1, (RBD-cRAF), to KRAS(G12C). The KRAS(G12C) Isoform A Coupled Nucleotide Exchange TR-FRET Assay Kit comes in a convenient 384-well format, with enough purified recombinant GDP-loaded KRAS(G12C) Isoform A, GTP, exchange factor SOS1 (son of sevenless homolog 1) (amino acids 564-1049), effector protein RBD-cRAF (amino acids 50-140), assay buffer and additives for 400 reactions. - Screen small molecule inhibitors or antagonists that affect KRAS(G12C) nucleotide-binding status in high throughput screening (HTS) applications. - Avoid freeze/thaw cycles
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
