Indole-3-pyruvic Acid
CAY-29876-1 1 g
Data Sheet: 
SDS:
SDS:
CAS
392-12-1
Formulation
A crystalline solid
Purity
≥98%
MW
203,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Indole-3-pyruvic acid is an endogenous metabolite of tryptophan and intermediate in the biosynthesis of the major auxin hormone, indole-3-acetic acid (IAA; Item No. 16954), in plants.{52871,52872,52873} Indole-3-pyruvic acid (50 and 250 µM) activates the aryl hydrocarbon receptor (AhR) in a reporter assay.{52871} It reduces UVB-induced cytotoxicity and the levels of COX-2 in HaCaT keratinocytes.{52874} Topical administration of indole-3-pyruvic acid (100 µmol) reduces the severity of UVB-induced damage in mouse skin. Dietary administration of indole-3-pyruvic acid (0.1%) reduces diarrhea, colonic inflammation, and the colonic expression of Il1b, Ifng, Tnfa, and Il12b in a mouse model of T cell-mediated colitis.{52871} It increases the time spent in the open arms of the elevated plus maze in mice when administered at a dose of 100 mg/kg.{52872} It also reverses the anxiogenic effect of caffeine (Item No. 14118) and 3-hydroxy kynurenine, but not pentylenetetrazole (Item No. 18682) or phenylethylamine, in the elevated plus maze in mice.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
