ILK-IN-2
CAY-36674-1 1 mg
Synonyms: CPD 22|Integrin-linked Kinase Inhibitor 1|OSU-T 315
Data Sheet: 
CAS
1333146-24-9
Formulation
A solid
Purity
≥98%
MW
533,587509
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An ILK inhibitor (IC50 = 0.6 µM); inhibits the phosphorylation of Akt, GSK3β, and MLC in PC3 and MDA-MB-231 cells from 1-4 µM; inhibits the proliferation of LNCaP, PC3, MDA-MB-231, MDA-MB-468, SK-BR-3, and MCF-7 cancer cells (IC50s = 1.6, 2, 1, 1.5, 1.8, and 2.5 µM, respectively); induces autophagy and apoptosis in PC3 cells at 2 µM; reduces protein levels of YB-1, HER2, and EGFR in PC3 cells; reduces tumor growth in a PC3 mouse xenograft model at 25 and 50 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
