IDH305
CAY-24107-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1628805-46-8
Formulation
A crystalline solid
Purity
≥98%
MW
490,453632
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A potent and selective inhibitor of mutant IDH1 (IC50s = 27, 28, and 6,140 nM for recombinant IDH1R132H, IDH1R132C, and wild-type IDH1, respectively); reduces 2-HG production and inhibits growth of MCF-10A-IDH1R132H/+ cells in a concentration-dependent manner; reduces concentration of tumor 2-HG in an HCT116-IDH1R132H/+ mouse xenograft model (200 mg/kg); suppresses 2-HG production and reduces tumor progression in an HMEX2838-IDH1R132C patient-derived melanoma mouse xenograft model (300 mg/kg)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
