IACS-010759
CAY-25867-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1570496-34-2
Formulation
A crystalline solid
Purity
≥98%
MW
562,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
IACS-010759 is an orally bioavailable inhibitor of complex I of the mitochondrial electron transport chain.{42644,42645} It inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I when used at a concentration of 60 nM.{42644} IACS-010759 (100 nM) reduces basal and spare respiratory capacities and increases glycolytic flux in primary chronic lymphocytic leukemia (CLL) cells.{42645} It also induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose (Item No. 14325). IACS-010759 (5 and 10 mg/ml) induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model.{42644}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
