Hypothemycin
CAY-27913-5 5 mg
Data Sheet: 
CAS
76958-67-3
Formulation
A solid
Purity
≥95%
MW
378,37318
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A resorcylic acid lactone polyketide with diverse biological activities; inhibits MEK (IC50 = 15 nM) and other protein kinases containing a conserved cysteine residue in the ATP-binding domain, including ERK, PDGFR, VEGF, PKD1, and MAPKAP5/MK5; inhibits TAK1 (IC50 = 33 nM); inhibits proliferation of A549, MV-4-11, and EOL1 cells (IC50s = 6, 0.006, and 0.0004 µM, respectively); reduces tumor growth in Ma44 and HCT116 mouse xenograft models at 25 mg/kg per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
