Hydroxysafflor Yellow A

  CAY-31204-1 1 mg

Data Sheet:     SDS:    

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78281-02-4  

A crystalline solid  

≥85%  

612,5  

-20  

-20  

1460  

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Description

 

Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}

 

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