HBX 41108
CAY-23759-1 1 mg
Data Sheet: 
CAS
924296-39-9
Formulation
A crystalline solid
Purity
≥95%
MW
266,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of USP7 (IC50 = 424 nM); dose-dependently inhibits USP7-mediated p53 deubiquitination in a cell-free assay (IC50 = ~0.8 µM) and in vitro; selective for USP7 over a panel of proteases including aspartic, serine, and metalloproteases (IC50s = >10 µM), several cysteine proteases (IC50s = >1 and >10 µM), and the deubiquitinating enzymes UCH-L1 (IC50 = >1 µM) and SENP1 (IC50 = >10 µM; increases p53 levels; inhibits proliferation of HCT116 cells (IC50 = ~1 µM); induces apoptosis in HCT116 cells
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
