GSK3326595
CAY-27305-25 25 mg
Data Sheet: 
CAS
1616392-22-3
Formulation
A solid
Purity
≥98%
MW
452,6
Shipment
-20
Long Term Storage
-20
Description
A PRMT5 inhibitor; inhibits methylation of peptides derived from histones H4 and H2A, SmD3, FUBP1, and HNRNPH1 by the PRMT5/MEP50 complex (IC50s = 5.9-19.7 nM); more than 4,000-fold selective for PRMT5/MEP50 over a panel of 20 methyltransferases; induces alternative splicing of MDM4 in Z-138, MCF-7, JM1, and DOHH-2 cells at 200 nM; increases p53 and p21 protein levels in Z-138 cells in a concentration-dependent manner; inhibits growth and SDMA methylation in several lymphoma and breast cancer cell lines; reduces tumor growth in a Z-138 mouse xenograft model at 25, 50, and 100 mg/kg twice per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
