GMQ (hydrochloride)
CAY-29760-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
5361-15-9
Formulation
A crystalline solid
Purity
≥95%
MW
237,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
GMQ is an activator of acid-sensing ion channel 3 (ASIC3).{54008} It evokes rapid inward currents with little desensitization in CHO cells expressing ASIC3 (EC50 = 67 µM at neutral pH). It is also an inhibitor of the GABAA receptor (IC50 = 0.39 µM in primary rat hippocampal neurons).{54009} GMQ has stimulatory effects on large-conductance calcium-activated potassium (KCa1.1/BKCa) channels in GH3 rat pituitary cells and on non-selective cation currents in Rolf B1.T olfactory sensory neurons.{54010} It increases paw licking time in Asic3+/+ and, to a lesser extent, Asic3-/- mice when administered at a dose of 100 µM, an effect that can be blocked by the ASIC inhibitor amiloride (Item No. 14409).{54008}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
