GDC-0879
CAY-16993-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
905281-76-7
Formulation
A crystalline solid
Purity
≥95%
MW
334,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of B-RafV600E (IC50 = 0.13 nM for human recombinant enzyme); selective for B-RafV600E over a panel of 140 kinases at 1 μM; inhibits phosphorylation of ERK in MALME-3M cells (IC50 = 63 nM) as well as phosphorylation of MEK1 in COLO 205 and A375 cells that express B-RafV600E (IC50s = 29 and 59 nM, respectively); inhibits tumor growth in an A375 mouse xenograft model from 15-200 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
